About the Collection

The Disease Collection Cell Catalog is a growing compilation of cell lines that carry mutations in genes known to cause disease. These cell lines were created by introducing a point mutation in one of the fluorescently tagged WTC-11 clonal lines from the Allen Cell Collection.

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Coriell

Disease models available in our collection

Updated User Experience Coming Soon!

Data for our lines will be added to this page in a user-friendly format later this year. In the meantime, access a large selection of QC and other data via the Certificate of Analysis associated with each line.

Cardiomyopathy

Cell Collection IDSNPGene Symbol & NameParental LineClones

AICS-0097

NM_000257.4(MYH7): c.767G>A(p.Gly256Glu)
MYH7myosin heavy chain 7
3 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

AICS-0104

NM_000257.4(MYH7): c.752C>A(p.His251Asn)
MYH7myosin heavy chain 7
2 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

AICS-0105

NM_000257.4(MYH7): c.1106G>A(p.Arg369Gln)
MYH7myosin heavy chain 7
4 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

AICS-0106

NM_000257.4(MYH7): c.872C>T(p.Ser291Phe)
MYH7myosin heavy chain 7
2 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

AICS-0107

NM_000257.4(MYH7): c.1816G>A(p.Val606Met)
MYH7myosin heavy chain 7
2 mutant clones
1 isogenic controls
Obtain Collection
Cert. of Analysis

AICS-0109

NM_000257.4(MYH7): c.1573G>A (p.Glu525Lys)
MYH7myosin heavy chain 7
2 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

These cell lines were generated at Allen Institute and released to a group of collaborators to perform preliminary studies. We would like to thank the following: Daniel Bernstein, MD, Stanford University, Soah Lee, PhD, Sungkyunkwan University, Beth Pruitt, PhD, University of California, Santa Barbara, Mike Regnier, PhD, University of Washington, James Spudich, PhD, Stanford University, Sean Wu, MD, PhD, Stanford School of Medicine

Laminopathy

Cell Collection IDSNPGene Symbol & NameParental LineClones

AICS-0119

NM_170707.4(LMNA): c.1824C>T(p.Gly608=)
LMNAlamin A/C
2 mutant clones
2 isogenic controls
Obtain Collection
Cert. of Analysis

These lines were generated at Allen Institute and released to a group of collaborators to perform preliminary studies. We would like to thank the following: Francis Collins, MD, PhD, NIH,  Michael Erdos, PhD, NIH, Zhengmei Xiong, PhD, NIH, Abigail Buchwalter, PhD, University of California, San Francisco

Skeletal Myopathy

Cell Collection IDSNPGene Symbol & NameParental LineClones

AICS-0113

NM_0027470.4(MYH3): c.2306G>T(p.Gly769Val)
MYH3myosin heavy chain 3
3 mutant clones
3 isogenic controls
Obtain Collection
Cert. of Analysis

These lines were generated at Allen Institute and released to a group of collaborators to perform skeletal differentiation. We would like to thank the following: Alina Greimal, BS, Christian Mandrycky, PhD and David Mack, PhD Institute for Stem Cell & Regenerative Medicine (ISCRM) at the University of Washington

All cell lines were originally generated using the WTC-11 hiPS cell line as the parental cell line. Access whole genome sequence data (100X coverage) for the WTC-11 line on the Genomics page. The donor of the WTC line has consented to the sharing of this data.